Chloroquine reduces hypercoagulability in pancreatic cancer through inhibition of neutrophil extracellular traps

Chloroquine reduces hypercoagulability in pancreatic cancer through inhibition of neutrophil extracellular traps

Abstract Background The hypercoagulable state associated with pancreatic adenocarcinoma (PDA) results in increased risk of venous thromboembolism, leading to substantial morbidity and mortality. Recently, neutrophil extracellular traps (NETs), whereby activated neutrophils release their intracellula...

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Bibliographic Details
Main Authors: Brian A. Boone, Pranav Murthy, Jennifer Miller-Ocuin, W. Reed Doerfler, Jarrod T. Ellis, Xiaoyan Liang, Mark A. Ross, Callen T. Wallace, Jason L. Sperry, Michael T. Lotze, Matthew D. Neal, Herbert J. Zeh
Format: Article
Language:English
Published: BMC 2018-06-01
Series:BMC Cancer
Subjects:
Chloroquine
Autophagy
Neutrophil extracellular traps (NETs)
Hypercoagulability
Venous thromboembolism
Online Access:http://link.springer.com/article/10.1186/s12885-018-4584-2

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http://link.springer.com/article/10.1186/s12885-018-4584-2

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