Antisense-Mediated Suppression of Heparanase Gene Inhibits Melanoma Cell Invasion

Antisense-Mediated Suppression of Heparanase Gene Inhibits Melanoma Cell Invasion

Cancer metastasis is a frequent manifestation of malignant melanoma progression. Successful invasion into distant organs by tumor cells must include attachment to microvessel endothelial cells, degradation of basement membranes and extracellular matrix (ECM). Heparan sulfate proteoglycans (HSPG) ar...

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Bibliographic Details
Main Authors: Madhuchhanda Roy, Jane Reiland, Brian P. Murry, Vladimir Chouljenko, Konstantin G. Kousoulas, Dario Marchetti
Format: Article
Language:English
Published: Elsevier 2005-03-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Malignant melanoma
heparanase
heparan sulfate
invasion and metastasis
anti-sense gene delivery
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558605800260

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http://www.sciencedirect.com/science/article/pii/S1476558605800260

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