Synthesis and Evaluation of New Oxadiazole, Thiadiazole, and Triazole Derivatives as Potential Anticancer Agents Targeting MMP-9

Synthesis and Evaluation of New Oxadiazole, Thiadiazole, and Triazole Derivatives as Potential Anticancer Agents Targeting MMP-9

Matrix metalloproteinases (MMPs) are important proteases involved in tumor progression including angiogenesis, tissue invasion, and migration. Therefore, MMPs have been reported as potential diagnostic and prognostic biomarkers in many types of cancer. New oxadiazole, thiadiazole, and triazole deriv...

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Bibliographic Details
Main Authors: Ahmet Özdemir, Belgin Sever, Mehlika Dilek Altıntop, Halide Edip Temel, Özlem Atlı, Merve Baysal, Fatih Demirci
Format: Article
Language:English
Published: MDPI AG 2017-07-01
Series:Molecules
Subjects:
oxadiazole
thiadiazole
triazole
anticancer activity
matrix metalloproteinase
docking studies
Online Access:https://www.mdpi.com/1420-3049/22/7/1109

Internet

https://www.mdpi.com/1420-3049/22/7/1109

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