Quasi-Irreversible Inhibition of CYP2D6 by Berberine

Quasi-Irreversible Inhibition of CYP2D6 by Berberine

In our previous study, Hwang-Ryun-Hae-Dok-Tang, which contains berberine (BBR) as a main active ingredient, inhibited cytochrome P450 (CYP) 2D6 in a quasi-irreversible manner. However, no information is available on the detailed mechanism of BBR-induced CYP2D6 inhibition. Thus, the present study aim...

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Bibliographic Details
Main Authors: Ha Gyeong Kim, Han Sol Lee, Jang Su Jeon, Young Jae Choi, Yeon Jung Choi, So-Yeol Yoo, Eun-yeong Kim, Kiho Lee, InWha Park, MinKyun Na, Han-Jin Park, Seung-Woo Cho, Jong-Hoon Kim, Jae-Young Lee, Sang Kyum Kim
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Pharmaceutics
Subjects:
berberine
cytochrome P450
herb-drug interaction
metabolite identification
drug metabolism
Online Access:https://www.mdpi.com/1999-4923/12/10/916

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https://www.mdpi.com/1999-4923/12/10/916

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