Radiolabeling and PET–MRI microdosing of the experimental cancer therapeutic, MN-anti-miR10b, demonstrates delivery to metastatic lesions in a murine model of metastatic breast cancer

Radiolabeling and PET–MRI microdosing of the experimental cancer therapeutic, MN-anti-miR10b, demonstrates delivery to metastatic lesions in a murine model of metastatic breast cancer

Abstract Background In our earlier work, we identified microRNA-10b (miR10b) as a master regulator of the viability of metastatic tumor cells. This knowledge allowed us to design a miR10b-targeted therapeutic consisting of an anti-miR10b antagomir conjugated to ultrasmall iron oxide nanoparticles (M...

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Bibliographic Details
Main Authors: Mariane Le Fur, Alana Ross, Pamela Pantazopoulos, Nicholas Rotile, Iris Zhou, Peter Caravan, Zdravka Medarova, Byunghee Yoo
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Cancer Nanotechnology
Subjects:
MicroRNA
RNA interference
Metastasis
Biodistribution
Positron emission tomography
MR imaging
Online Access:https://doi.org/10.1186/s12645-021-00089-5

Internet

https://doi.org/10.1186/s12645-021-00089-5

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