Interleukin-36β provides protection against HSV-1 infection, but does not modulate initiation of adaptive immune responses

Abstract Interleukin-36 (IL-36) represents three cytokines, IL-36α, IL-36β and IL-36γ, which bind to the same receptor, IL-1RL2; however, their physiological function(s) remain poorly understood. Here, the role of IL-36 in immunity against HSV-1 was examined using the flank skin infection mouse mode...

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Bibliographic Details
Main Authors: Katelynn A. Milora, Siva R. Uppalapati, Julio C. Sanmiguel, Wei Zou, Liselotte E. Jensen
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-05363-4