Scavenging of highly reactive gamma-ketoaldehydes attenuates cognitive dysfunction associated with epileptogenesis

Cognitive dysfunction is a major comorbidity of the epilepsies; however, treatments targeting seizure-associated cognitive dysfunction, particularly deficits in learning and memory are not available. Isoketals and neuroketals, collectively known as gamma-ketoaldehydes are formed via the non-enzymati...

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Bibliographic Details
Main Authors: Jennifer N. Pearson, Eric Warren, Li-Ping Liang, L. Jackson Roberts, II, Manisha Patel
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116302790