Recurrent tumor-specific regulation of alternative polyadenylation of cancer-related genes

Recurrent tumor-specific regulation of alternative polyadenylation of cancer-related genes

Abstract Background Alternative polyadenylation (APA) results in messenger RNA molecules with different 3′ untranslated regions (3’ UTRs), affecting the molecules’ stability, localization, and translation. APA is pervasive and implicated in cancer. Earlier reports on APA focused on 3’ UTR length mod...

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Bibliographic Details
Main Authors: Zhuyi Xue, René L. Warren, Ewan A. Gibb, Daniel MacMillan, Johnathan Wong, Readman Chiu, S. Austin Hammond, Chen Yang, Ka Ming Nip, Catherine A. Ennis, Abigail Hahn, Sheila Reynolds, Inanc Birol
Format: Article
Language:English
Published: BMC 2018-07-01
Series:BMC Genomics
Subjects:
Alternative polyadenylation
Cancer
3’ UTR
Cleavage site
RNA-Seq
de novo assembly
Online Access:http://link.springer.com/article/10.1186/s12864-018-4903-7

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http://link.springer.com/article/10.1186/s12864-018-4903-7

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