A Fluorescence Polarization-Based High-Throughput Screen to Identify the First Small-Molecule Modulators of the Human Adenylyltransferase HYPE/FICD

A Fluorescence Polarization-Based High-Throughput Screen to Identify the First Small-Molecule Modulators of the Human Adenylyltransferase HYPE/FICD

The covalent transfer of the AMP portion of ATP onto a target protein—termed adenylylation or AMPylation—by the human Fic protein HYPE/FICD has recently garnered attention as a key regulatory mechanism in endoplasmic reticulum homeostasis, neurodegeneration, and neurogenesis. As a central player in...

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Bibliographic Details
Main Authors: Ali Camara, Alyssa George, Evan Hebner, Anika Mahmood, Jashun Paluru, Seema Mattoo
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
HYPE/FICD
AMPylation/adenylylation
post-translational modification
BiP/GRP78/HSPA5
α-synuclein
fluorescence polarization
Online Access:https://www.mdpi.com/1422-0067/21/19/7128

Internet

https://www.mdpi.com/1422-0067/21/19/7128

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