Peroxiredoxin promotes longevity and H2O2-resistance in yeast through redox-modulation of protein kinase A

Peroxiredoxin promotes longevity and H2O2-resistance in yeast through redox-modulation of protein kinase A

Peroxiredoxins are H2O2 scavenging enzymes that also carry out H2O2 signaling and chaperone functions. In yeast, the major cytosolic peroxiredoxin, Tsa1 is required for both promoting resistance to H2O2 and extending lifespan upon caloric restriction. We show here that Tsa1 effects both these functi...

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Bibliographic Details
Main Authors: Friederike Roger, Cecilia Picazo, Wolfgang Reiter, Marouane Libiad, Chikako Asami, Sarah Hanzén, Chunxia Gao, Gilles Lagniel, Niek Welkenhuysen, Jean Labarre, Thomas Nyström, Morten Grøtli, Markus Hartl, Michel B Toledano, Mikael Molin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-07-01
Series:eLife
Subjects:
aging
H2O2 signalling
peroxiredoxin
protein kinase A
cysteine sulfenylation
glutathionylation
Online Access:https://elifesciences.org/articles/60346

Internet

https://elifesciences.org/articles/60346

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