Inhibition of FAK Signaling Elicits Lamin A/C-Associated Nuclear Deformity and Cellular Senescence

Inhibition of FAK Signaling Elicits Lamin A/C-Associated Nuclear Deformity and Cellular Senescence

Focal adhesion kinase (FAK) is a non-receptor kinase that facilitates tumor aggressiveness. The effects of FAK inhibition include arresting proliferation, limiting metastasis, and inhibiting angiogenesis. PF-573228 is an ATP-competitive inhibitor of FAK. Treating lung cancer cells with PF-573228 res...

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Bibliographic Details
Main Authors: Hsiang-Hao Chuang, Pei-Hui Wang, Sheng-Wen Niu, Yen-Yi Zhen, Ming-Shyan Huang, Michael Hsiao, Chih-Jen Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Oncology
Subjects:
non-small cell lung cancer
senescence
focal adhesion kinase
nuclear deformity
lamin A/C
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00022/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.00022/full

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