Continuous twin screw granulation: Impact of microcrystalline cellulose batch-to-batch variability during granulation and drying – A QbD approach

Continuous twin screw granulation: Impact of microcrystalline cellulose batch-to-batch variability during granulation and drying – A QbD approach

Despite significant advances in the research domain of continuous twin screw granulation, limited information is currently available on the impact of raw material properties, especially considering batch-to-batch variability. The importance of raw material variability and subsequent mitigation of th...

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Bibliographic Details
Main Authors: Christoph Portier, Tamas Vigh, Giustino Di Pretoro, Jan Leys, Didier Klingeleers, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:International Journal of Pharmaceutics: X
Subjects:
Continuous manufacturing
Twin screw granulation
Wet granulation
Formulation development
Batch-to-batch variability
Quality-by-Design
Online Access:http://www.sciencedirect.com/science/article/pii/S2590156721000062

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http://www.sciencedirect.com/science/article/pii/S2590156721000062

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