Suppressive oligodeoxynucleotides promote the development of Th17 cells.

Synthetic oligonucleotides containing repetitive TTAGGG motifs mimic the immunosuppressive activity of telomeric DNA. These suppressive oligonucleotides (Sup ODN) are effective in the treatment/prevention of various inflammatory and autoimmune diseases in mice. The therapeutic activity of Sup ODN wa...

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Bibliographic Details
Main Authors: Christian Bode, Xiang-Ping Yang, Hiu Kiu, Dennis M Klinman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3699503?pdf=render