The Crucial Role of Xanthine Oxidase in CKD Progression Associated with Hypercholesterolemia

The Crucial Role of Xanthine Oxidase in CKD Progression Associated with Hypercholesterolemia

In the present study, we investigated the effects of xanthine oxidase (XO) inhibition on cholesterol-induced renal dysfunction in chronic kidney disease (CKD) mice, and in low-density lipoprotein (LDL)-treated human kidney proximal tubule epithelial (HK-2) cells. ApoE knockout (KO) mice underwent un...

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Bibliographic Details
Main Authors: You-Jin Kim, Se-Hyun Oh, Ji-Sun Ahn, Ju-Min Yook, Chan-Duck Kim, Sun-Hee Park, Jang-Hee Cho, Yong-Lim Kim
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
chronic kidney disease
hypercholesterolemia
xanthine oxidase
inflammation
fibrosis
NF-κB pathway
Online Access:https://www.mdpi.com/1422-0067/21/20/7444

Internet

https://www.mdpi.com/1422-0067/21/20/7444

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