Plasma cholesterol-lowering and transient liver dysfunction in mice lacking squalene synthase in the liver

Plasma cholesterol-lowering and transient liver dysfunction in mice lacking squalene synthase in the liver

Squalene synthase (SS) catalyzes the biosynthesis of squalene, the first specific intermediate in the cholesterol biosynthetic pathway. To test the feasibility of lowering plasma cholesterol by inhibiting hepatic SS, we generated mice in which SS is specifically knocked out in the liver (L-SSKO) usi...

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Bibliographic Details
Main Authors: Shuichi Nagashima, Hiroaki Yagyu, Ryuichi Tozawa, Fumiko Tazoe, Manabu Takahashi, Tetsuya Kitamine, Daisuke Yamamuro, Kent Sakai, Motohiro Sekiya, Hiroaki Okazaki, Jun-ichi Osuga, Akira Honda, Shun Ishibashi
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:Journal of Lipid Research
Subjects:
cholesterol/biosynthesis
enzymology/enzyme regulation
lipoproteins/metabolism
very low density lipoprotein
inborn errors of metabolism
Cre recombinase
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520312396

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http://www.sciencedirect.com/science/article/pii/S0022227520312396

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