Recent data concerning heparanase: focus on fibrosis, inflammation and cancer

Recent data concerning heparanase: focus on fibrosis, inflammation and cancer

Heparanase (HPSE) is a multitasking protein characterized by enzymatic and non-enzymatic activities. By means of its enzymatic activity, HPSE catalyzes the cutting of the side chains of heparan sulfate (HS) proteoglycans, thereby inducing the remodeling of the extracellular matrix and basement membr...

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Bibliographic Details
Main Authors: Secchi Maria Francesca, Masola Valentina, Zaza Gianluigi, Lupo Antonio, Gambaro Giovanni, Onisto Maurizio
Format: Article
Language:English
Published: De Gruyter 2015-12-01
Series:Biomolecular Concepts
Subjects:
cancer
extracellular matrix
fibrosis
heparan sulfate
heparanase
inflammation
Online Access:https://doi.org/10.1515/bmc-2015-0021

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