Identifying regulators for EAG1 channels with a novel electrophysiology and tryptophan fluorescence based screen.

Ether-à-go-go (EAG) channels are expressed throughout the central nervous system and are also crucial regulators of cell cycle and tumor progression. The large intracellular amino- and carboxy- terminal domains of EAG1 each share similarity with known ligand binding motifs in other proteins, yet EAG...

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Bibliographic Details
Main Authors: Tinatin I Brelidze, Anne E Carlson, Douglas R Davies, Lance J Stewart, William N Zagotta
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-09-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2932742?pdf=render