Generation of a Genetically Modified Chimeric Plasmodium falciparum Parasite Expressing Plasmodium vivax Circumsporozoite Protein for Malaria Vaccine Development

Generation of a Genetically Modified Chimeric Plasmodium falciparum Parasite Expressing Plasmodium vivax Circumsporozoite Protein for Malaria Vaccine Development

Chimeric rodent malaria parasites with the endogenous circumsporozoite protein (csp) gene replaced with csp from the human parasites Plasmodium falciparum (Pf) and P. vivax (Pv) are used in preclinical evaluation of CSP vaccines. Chimeric rodent parasites expressing PfCSP have also been assessed as...

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Bibliographic Details
Main Authors: Yukiko Miyazaki, Catherin Marin-Mogollon, Takashi Imai, António M. Mendes, Rianne van der Laak, Angelika Sturm, Fiona J. A. Geurten, Shinya Miyazaki, Severine Chevalley-Maurel, Jai Ramesar, Surendra K. Kolli, Hans Kroeze, Roos van Schuijlenburg, Ahmed M. Salman, Brandon K. Wilder, Arturo Reyes-Sandoval, Koen J. Dechering, Miguel Prudêncio, Chris J. Janse, Shahid M. Khan, Blandine Franke-Fayard
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
malaria
Plasmodium falciparum
Plasmodium vivax
circumsporozoite protein (CSP)
chimeric parasites
vaccines
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2020.591046/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2020.591046/full

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