NF-κB and IRF7 Pathway Activation by Epstein-Barr Virus Latent Membrane Protein 1

NF-κB and IRF7 Pathway Activation by Epstein-Barr Virus Latent Membrane Protein 1

The principal Epstein-Barr virus (EBV) oncoprotein, Latent Membrane Protein 1 (LMP1), is expressed in most EBV-associated human malignancies. LMP1 mimics CD40 receptor signaling to provide infected cells with constitutive NF-κB, MAP kinase, IRF7, and PI3 kinase pathway stimulation. EBV-transformed B...

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Bibliographic Details
Main Authors: Benjamin E. Gewurz, Ina Ersing, Katharina Bernhardt
Format: Article
Language:English
Published: MDPI AG 2013-06-01
Series:Viruses
Subjects:
herpesvirus
apoptosis
cancer
innate immunity
transformation
integral membrane protein
signal transduction
proliferation
ubiquitin
lymphoma
oncogene
Online Access:http://www.mdpi.com/1999-4915/5/6/1587

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http://www.mdpi.com/1999-4915/5/6/1587

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