Genistein inhibits stemness of SKOV3 cells induced by macrophages co-cultured with ovarian cancer stem-like cells through IL-8/STAT3 axis

Genistein inhibits stemness of SKOV3 cells induced by macrophages co-cultured with ovarian cancer stem-like cells through IL-8/STAT3 axis

Abstract Background Recent studies showed that macrophages co-cultured with ovarian cancer stem-like cells (OCSLCs) induced SKOV3 cell stemness via IL-8/STAT3 signaling. Genistein (GEN) demonstrates chemopreventive activity in inflammation-associated cancers. The present study aimed to examine wheth...

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Bibliographic Details
Main Authors: Yingxia Ning, Weifeng Feng, Xiaocheng Cao, Kaiqun Ren, Meifang Quan, A. Chen, Chang Xu, Yebei Qiu, Jianguo Cao, Xiang Li, Xin Luo
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Ovarian cancer
Tumor associated macrophages
Ovarian cancer stem-like cells
Genistein
IL-8/STAT3 axis
Online Access:http://link.springer.com/article/10.1186/s13046-018-1010-1

Internet

http://link.springer.com/article/10.1186/s13046-018-1010-1

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