Amino-acid site variability among natural and designed proteins

Computational protein design attempts to create protein sequences that fold stably into pre-specified structures. Here we compare alignments of designed proteins to alignments of natural proteins and assess how closely designed sequences recapitulate patterns of sequence variation found in natural p...

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Bibliographic Details
Main Authors: Eleisha L. Jackson, Noah Ollikainen, Arthur W. Covert III, Tanja Kortemme, Claus O. Wilke
Format: Article
Language:English
Published: PeerJ Inc. 2013-11-01
Series:PeerJ
Subjects:
Online Access:https://peerj.com/articles/211.pdf