Haploinsufficiency of autism causative gene Tbr1 impairs olfactory discrimination and neuronal activation of the olfactory system in mice

Haploinsufficiency of autism causative gene Tbr1 impairs olfactory discrimination and neuronal activation of the olfactory system in mice

Abstract Background Autism spectrum disorders (ASD) exhibit two clusters of core symptoms, i.e., social and communication impairment, and repetitive behaviors and sensory abnormalities. Our previous study demonstrated that TBR1, a causative gene of ASD, controls axonal projection and neuronal activa...

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Bibliographic Details
Main Authors: Tzyy-Nan Huang, Tzu-Li Yen, Lily R. Qiu, Hsiu-Chun Chuang, Jason P. Lerch, Yi-Ping Hsueh
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Molecular Autism
Subjects:
Autism spectrum disorders
C-FOS
D-cycloserine
Neuronal activation
Olfactory bulb
Olfactory discrimination
Online Access:http://link.springer.com/article/10.1186/s13229-019-0257-5

Internet

http://link.springer.com/article/10.1186/s13229-019-0257-5

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