Computational investigation of potential dosing schedules for a switch of medication from warfarin to rivaroxaban – an oral, direct Factor Xa inhibitor

Computational investigation of potential dosing schedules for a switch of medication from warfarin to rivaroxaban – an oral, direct Factor Xa inhibitor

The long-lasting anticoagulant effect of vitamin K antagonists can be problematic in cases of adverse drug reactions or when patients are switched to another anticoagulant therapy. The objective of this study was to examine in silico the anticoagulant effect of rivaroxaban, an oral, direct Factor Xa...

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Bibliographic Details
Main Authors: Rolf eBurghaus, Katrin eCoboeken, Thomas eGaub, Christoph eNiederalt, Anke eSensse, Hans-Ulrich eSiegmund, Wolfgang eWeiss, Wolfgang eMueck, Takahiko eTanigawa, Joerg eLippert
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-11-01
Series:Frontiers in Physiology
Subjects:
Warfarin
simulation
mathematical modeling
Pharmacodynamics
coagulation
combination therapy
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00417/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00417/full

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