Afatinib induces pro-survival autophagy and increases sensitivity to apoptosis in stem-like HNSCC cells

Afatinib induces pro-survival autophagy and increases sensitivity to apoptosis in stem-like HNSCC cells

Abstract Afatinib, a second-generation tyrosine kinase inhibitor (TKI), exerts its antitumor effects in head and neck squamous cell carcinoma (HNSCC) by inducing intrinsic apoptosis through suppression of mTORC1. However, the detailed mechanism and biological significance of afatinib-induced autopha...

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Bibliographic Details
Main Authors: Xianfang Liu, Huiyuan Suo, Shengli Zhou, Zhenxing Hou, Mingqiang Bu, Xiuxiu Liu, Wei Xu
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-04011-0

Internet

https://doi.org/10.1038/s41419-021-04011-0

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