Melanoma cells replicate through chemotherapy by reducing levels of key homologous recombination protein RAD51 and increasing expression of translesion synthesis DNA polymerase ζ

Melanoma cells replicate through chemotherapy by reducing levels of key homologous recombination protein RAD51 and increasing expression of translesion synthesis DNA polymerase ζ

Abstract Background The global incidence of melanoma has been increasing faster than any other form of cancer. New therapies offer exciting prospects for improved survival, but the development of resistance is a major problem and there remains a need for additional effective melanoma therapy. Platin...

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Bibliographic Details
Main Authors: Liang Song, Ewan M. McNeil, Ann-Marie Ritchie, Katy R. Astell, Charlie Gourley, David W. Melton
Format: Article
Language:English
Published: BMC 2017-12-01
Series:BMC Cancer
Subjects:
Melanoma
Chemotherapy
Cisplatin
DNA repair
RAD51
Translesion synthesis
Online Access:http://link.springer.com/article/10.1186/s12885-017-3864-6

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http://link.springer.com/article/10.1186/s12885-017-3864-6

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