Persistent Activation of mRNA Translation by Transient Hsp90 Inhibition

Persistent Activation of mRNA Translation by Transient Hsp90 Inhibition

Summary: The heat shock protein 90 (Hsp90) chaperone functions as a protein-folding buffer and plays a role promoting the evolution of new heritable traits. To better understand how Hsp90 can affect mRNA translation, we screen more than 1,600 factors involved in mRNA regulation for physical interact...

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Bibliographic Details
Main Authors: Peter Tsvetkov, Timothy J. Eisen, Sven U. Heinrich, Zarina Brune, Erinc Hallacli, Greg A. Newby, Can Kayatekin, David Pincus, Susan Lindquist
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Cell Reports
Subjects:
prions
epigentic regualtion
cellular memory
mRNA translation
Hsp90
yeast
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720309864

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