Genetic polymorphisms in the endothelial nitric oxide synthase gene correlate with overall survival in advanced non-small-cell lung cancer patients treated with platinum-based doublet chemotherapy

Genetic polymorphisms in the endothelial nitric oxide synthase gene correlate with overall survival in advanced non-small-cell lung cancer patients treated with platinum-based doublet chemotherapy

<p>Abstract</p> <p>Background</p> <p>Nitric oxide (NO) is a free radical that is involved in carcinogenesis. Endothelial NO, synthesized from L-arginine by endothelial NO synthase (eNOS), inhibits apoptosis and promotes angiogenesis, tumor cell proliferation and metasta...

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Bibliographic Details
Main Authors: Mio Tadashi, Kim Young, Kaji Reiko, Hata Akito, Fukuhara Akiko, Hatachi Yukimasa, Masago Katsuhiro, Fujita Shiro, Mishima Michiaki, Katakami Nobuyuki
Format: Article
Language:English
Published: BMC 2010-11-01
Series:BMC Medical Genetics
Online Access:http://www.biomedcentral.com/1471-2350/11/167

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http://www.biomedcentral.com/1471-2350/11/167

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