Deep-learning-based three-dimensional label-free tracking and analysis of immunological synapses of CAR-T cells

The immunological synapse (IS) is a cell-cell junction between a T cell and a professional antigen-presenting cell. Since the IS formation is a critical step for the initiation of an antigen-specific immune response, various live-cell imaging techniques, most of which rely on fluorescence microscopy...

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Bibliographic Details
Main Authors: Moosung Lee, Young-Ho Lee, Jinyeop Song, Geon Kim, YoungJu Jo, HyunSeok Min, Chan Hyuk Kim, YongKeun Park
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-12-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/49023