Photo-switchable tweezers illuminate pore-opening motions of an ATP-gated P2X ion channel

Photo-switchable tweezers illuminate pore-opening motions of an ATP-gated P2X ion channel

P2X receptors function by opening a transmembrane pore in response to extracellular ATP. Recent crystal structures solved in apo and ATP-bound states revealed molecular motions of the extracellular domain following agonist binding. However, the mechanism of pore opening still remains controversial....

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Bibliographic Details
Main Authors: Chloé Habermacher, Adeline Martz, Nicolas Calimet, Damien Lemoine, Laurie Peverini, Alexandre Specht, Marco Cecchini, Thomas Grutter
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-01-01
Series:eLife
Subjects:
P2X receptors
azobenzene photoswitch
gating mechanism
Online Access:https://elifesciences.org/articles/11050

Internet

https://elifesciences.org/articles/11050

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