Drug-Induced Conformational Population Shifts in Topoisomerase-DNA Ternary Complexes

Drug-Induced Conformational Population Shifts in Topoisomerase-DNA Ternary Complexes

Type II topoisomerases (TOP2) are enzymes that resolve the topological problems during DNA replication and transcription by transiently cleaving both strands and forming a cleavage complex with the DNA. Several prominent anti-cancer agents inhibit TOP2 by stabilizing the cleavage complex and engende...

Full description

Bibliographic Details
Main Authors: Nan-Lan Huang, Jung-Hsin Lin
Format: Article
Language:English
Published: MDPI AG 2014-06-01
Series:Molecules
Subjects:
topoisomerases II
molecular docking
molecular dynamics simulations
computer-aided drug design
Online Access:http://www.mdpi.com/1420-3049/19/6/7415

Internet

http://www.mdpi.com/1420-3049/19/6/7415

Similar Items