Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension

Summary: Concentric lung vascular wall thickening due to enhanced proliferation of pulmonary arterial smooth muscle cells is an important pathological cause for the elevated pulmonary vascular resistance reported in patients with pulmonary arterial hypertension. We identified a differential role of...

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Main Authors: Haiyang Tang, PhD, Kang Wu, MD, PhD, Jian Wang, MD, Sujana Vinjamuri, MD, MS, Yali Gu, MS, RN, Shanshan Song, MD, PhD, Ziyi Wang, MD, Qian Zhang, MD, Angela Balistrieri, Ramon J. Ayon, PhD, Franz Rischard, MD, Rebecca Vanderpool, PhD, Jiwang Chen, PhD, Guofei Zhou, PhD, Ankit A. Desai, MD, Stephen M. Black, PhD, Joe G.N. Garcia, MD, Jason X.-J. Yuan, MD, PhD, Ayako Makino, PhD
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:JACC: Basic to Translational Science
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X18302316

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http://www.sciencedirect.com/science/article/pii/S2452302X18302316

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