Unbalance Between Sarcoplasmic Reticulum Ca2 + Uptake and Release: A First Step Toward Ca2 + Triggered Arrhythmias and Cardiac Damage

Unbalance Between Sarcoplasmic Reticulum Ca2 + Uptake and Release: A First Step Toward Ca2 + Triggered Arrhythmias and Cardiac Damage

The present review focusses on the regulation and interplay of cardiac SR Ca2+ handling proteins involved in SR Ca2+ uptake and release, i.e., SERCa2/PLN and RyR2. Both RyR2 and SERCA2a/PLN are highly regulated by post-translational modifications and/or different partners’ proteins. These control me...

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Bibliographic Details
Main Authors: Marilén Federico, Carlos A. Valverde, Alicia Mattiazzi, Julieta Palomeque
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Physiology
Subjects:
sarcoplasmic reticulum Ca2+-ATPase
ryanodine receptor 2
arrhythimas
phospholamban
apoptosis
diabetic myocardiopathy
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.01630/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.01630/full

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