Study on changes of endogenous metabolites in olfactory bulb of early⁃stage Parkinson's disease induced by SNCA gene Ala53Thr base substitution in mice

Study on changes of endogenous metabolites in olfactory bulb of early⁃stage Parkinson's disease induced by SNCA gene Ala53Thr base substitution in mice

Objective To explore the pathophysiologic mechanism of SNCA gene in the early⁃stage of Parkinson's disease (PD). Methods Wild type (WT group, n=10) and SNCA Ala53Thr base substitution mice (TG group, n=10) were selected for further experiments. Endogenous metabolites in olfactory bulb (OB) of t...

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Bibliographic Details
Main Authors: CHEN Ning, SUI Yun⁃peng, MENG Fan⁃gang
Format: Article
Language:English
Published: Tianjin Huanhu Hospital 2021-06-01
Series:Chinese Journal of Contemporary Neurology and Neurosurgery
Subjects:
parkinson disease
alpha⁃synuclein
genes
mutation
metabolomics
olfactory bulb
chromatography
liquid
Online Access:http://www.cjcnn.org/index.php/cjcnn/article/view/2349

Internet

http://www.cjcnn.org/index.php/cjcnn/article/view/2349

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