Listeria monocytogenes Relies on the Heme-Regulated Transporter hrtAB to Resist Heme Toxicity and Uses Heme as a Signal to Induce Transcription of lmo1634, Encoding Listeria Adhesion Protein

Listeria monocytogenes Relies on the Heme-Regulated Transporter hrtAB to Resist Heme Toxicity and Uses Heme as a Signal to Induce Transcription of lmo1634, Encoding Listeria Adhesion Protein

For pathogenic bacteria, host-derived heme represents an important metabolic cofactor and a source for iron. However, high levels of heme are toxic to bacteria. We have previously shown that excess heme has a growth-inhibitory effect on the Gram-positive foodborne pathogen Listeria monocytogenes, an...

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Bibliographic Details
Main Authors: Patrícia Teixeira dos Santos, Pernille Tholund Larsen, Pilar Menendez-Gil, Eva Maria Sternkopf Lillebæk, Birgitte Haahr Kallipolitis
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Microbiology
Subjects:
Listeria monocytogenes
heme toxicity
heme detoxification
hrtAB
LAP
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.03090/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.03090/full

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