Combination of Size-Exclusion Chromatography and Ultracentrifugation Improves the Proteomic Profiling of Plasma-Derived Small Extracellular Vesicles

Combination of Size-Exclusion Chromatography and Ultracentrifugation Improves the Proteomic Profiling of Plasma-Derived Small Extracellular Vesicles

Abstract Background Circulating small extracellular vesicles (sEVs) and its associated proteins are of great interest in the early detection of many diseases. However, there is no gold standard for plasma sEVs isolation, especially for proteomic profiling which could be largely affected by contamina...

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Bibliographic Details
Main Authors: Rui Wei, Libo Zhao, Guanyi Kong, Xiang Liu, Shengtao Zhu, Shutian Zhang, Li Min
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Biological Procedures Online
Subjects:
Extracellular vesicles
Size-exclusion chromatography
Ultracentrifugation
Proteomics
Online Access:http://link.springer.com/article/10.1186/s12575-020-00125-5

Internet

http://link.springer.com/article/10.1186/s12575-020-00125-5

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