Prolactin-induced neuroprotection against glutamate excitotoxicity is mediated by the reduction of [Ca2+]i overload and NF-κB activation.

Prolactin-induced neuroprotection against glutamate excitotoxicity is mediated by the reduction of [Ca2+]i overload and NF-κB activation.

Prolactin (PRL) is a peptidic hormone that displays pleiotropic functions in the organism including different actions in the brain. PRL exerts a neuroprotective effect against excitotoxicity produced by glutamate (Glu) or kainic acid in both in vitro and in vivo models. It is well known that Glu exc...

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Bibliographic Details
Main Authors: Nadia A Rivero-Segura, Edgar Flores-Soto, Selene García de la Cadena, Isabel Coronado-Mares, Juan C Gomez-Verjan, Diana G Ferreira, Erika Alejandra Cabrera-Reyes, Luísa V Lopes, Lourdes Massieu, Marco Cerbón
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5419567?pdf=render

Internet

http://europepmc.org/articles/PMC5419567?pdf=render

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