The Impact and Mechanism of a Novel Allosteric AMPA Receptor Modulator LCX001 on Protection Against Respiratory Depression in Rodents

The Impact and Mechanism of a Novel Allosteric AMPA Receptor Modulator LCX001 on Protection Against Respiratory Depression in Rodents

Analgesics and sedative hypnotics in clinical use often give rise to significant side effects, particularly respiratory depression. For emergency use, specific antagonists are currently administered to counteract respiratory depression. However, antagonists are often short-lasting and eliminate drug...

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Bibliographic Details
Main Authors: Wei Dai, Xiang Gao, Dian Xiao, Yu-Lei Li, Xin-Bo Zhou, Zheng Yong, Rui-Bin Su
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Pharmacology
Subjects:
respiratory depression
glutamate
AMPA receptor modulator
ampakine
analgesics and sedative drugs
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00105/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00105/full

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