Kaurenoic Acid Possesses Leishmanicidal Activity by Triggering a NLRP12/IL-1β/cNOS/NO Pathway

Kaurenoic Acid Possesses Leishmanicidal Activity by Triggering a NLRP12/IL-1β/cNOS/NO Pathway

Leishmania amazonensis (L. amazonensis) infection can cause severe local and diffuse injuries in humans, a condition clinically known as American cutaneous leishmaniasis (ACL). Currently, the therapeutic approach for ACL is based on Glucantime, which shows high toxicity and poor effectiveness. There...

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Bibliographic Details
Main Authors: Milena Menegazzo Miranda, Carolina Panis, Suelen Santos da Silva, Juliana Aparecida Macri, Natalia Yoshie Kawakami, Thiago Hideki Hayashida, Tiago Bervelieri Madeira, Vinicius Ricardo Acquaro, Suzana Lucy Nixdorf, Luciana Pizzatti, Sérgio Ricardo Ambrósio, Rubens Cecchini, Nilton Syogo Arakawa, Waldiceu Aparecido Verri, Ivete Conchon Costa, Wander Rogério Pavanelli
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2015/392918

Internet

http://dx.doi.org/10.1155/2015/392918

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