Generation of two RNF2 homozygous knockout human embryonic stem cell lines by CRISPR/Cas9 system

Generation of two RNF2 homozygous knockout human embryonic stem cell lines by CRISPR/Cas9 system

Human RNF2 (RING1B) gene is a critical epigenetic modification factor for embryonic development, pluripotency and differentiation of embryonic stem cells (ESCs). To further gain insights into the role of RNF2 in cell fate decisions of human ESCs, here we generated two RNF2 homozygous knockout human...

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Bibliographic Details
Main Authors: Yongli Shan, Lishi Ma, Cong Zhang, Yanqi Zhang, Jingyuan Zhang, Lu Xiao, Yanxing Wei, Yanhong Yu
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506120301860

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http://www.sciencedirect.com/science/article/pii/S1873506120301860

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