Cyclic AMP Response Element Binding Protein Mediates Pathological Retinal Neovascularization via Modulating DLL4-NOTCH1 Signaling

Cyclic AMP Response Element Binding Protein Mediates Pathological Retinal Neovascularization via Modulating DLL4-NOTCH1 Signaling

Retinal neovascularization is the most common cause of moderate to severe vision loss in all age groups. Despite the use of anti-VEGFA therapies, this complication continues to cause blindness, suggesting a role for additional molecules in retinal neovascularization. Besides VEGFA and VEGFB, hypoxia...

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Bibliographic Details
Main Authors: Nikhlesh K. Singh, Sivareddy Kotla, Raj Kumar, Gadiparthi N. Rao
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:EBioMedicine
Subjects:
CREB
DLL4
NOTCH1
VEGFC
Retinal neovascularization***
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396415301584

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http://www.sciencedirect.com/science/article/pii/S2352396415301584

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