Epigallocatechin-3-gallate enhances key enzymatic activities of hepatic thioredoxin and glutathione systems in selenium-optimal mice but activates hepatic Nrf2 responses in selenium-deficient mice

Epigallocatechin-3-gallate enhances key enzymatic activities of hepatic thioredoxin and glutathione systems in selenium-optimal mice but activates hepatic Nrf2 responses in selenium-deficient mice

Selenium participates in the antioxidant defense mainly through a class of selenoproteins, including thioredoxin reductase. Epigallocatechin-3-gallate (EGCG) is the most abundant and biologically active catechin in green tea. Depending upon the dose and biological systems, EGCG may function either a...

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Bibliographic Details
Main Authors: Ruixia Dong, Dongxu Wang, Xiaoxiao Wang, Ke Zhang, Pingping Chen, Chung S. Yang, Jinsong Zhang
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Redox Biology
Subjects:
Epigallocatechin-3-gallate
Selenium
Thioredoxin system
Glutathione system
Nrf2 response
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231716302129

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http://www.sciencedirect.com/science/article/pii/S2213231716302129

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