Herpes Simplex Virus Type 1 Infects Enteric Neurons and Triggers Gut Dysfunction via Macrophage Recruitment

Herpes Simplex Virus Type 1 Infects Enteric Neurons and Triggers Gut Dysfunction via Macrophage Recruitment

Herpes Simplex Virus type 1 (HSV-1), a neurotropic pathogen widespread in human population, infects the enteric nervous system (ENS) in humans and rodents and causes intestinal neuromuscular dysfunction in rats. Although infiltration of inflammatory cells in the myenteric plexus and neurodegeneratio...

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Bibliographic Details
Main Authors: Paola Brun, Marsela Qesari, Peggy C. Marconi, Andromachi Kotsafti, Andrea Porzionato, Veronica Macchi, Reto A. Schwendener, Marco Scarpa, Maria C. Giron, Giorgio Palù, Arianna Calistri, Ignazio Castagliuolo
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
neurotropic virus
enteric neuropathies
inflammation
neuromuscular dysfunction
macrophage recruitment
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2018.00074/full

Internet

http://journal.frontiersin.org/article/10.3389/fcimb.2018.00074/full

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