Selective H3 Antagonist (ABT-239) Differentially Modifies Cognitive Function Under the Impact of Restraint Stress

Background: A considerable number of competitive antagonists/inverse agonists of histamine H3 receptor (H3R) have progressed to clinical assessment, with pitolisant approved for the treatment of narcolepsy. H3R, highly expressed in the CNS, is regarded as a relevant target in CNS disorders. At the s...

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Bibliographic Details
Main Authors: Emil Trofimiuk, Przemysław Wielgat, Halina Car
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Systems Neuroscience
Subjects:
rat
Online Access:https://www.frontiersin.org/articles/10.3389/fnsys.2020.614810/full