Neutrophil extracellular trap regulators in sickle cell disease: Modulation of gene expression of PADI4, neutrophil elastase, and myeloperoxidase during vaso‐occlusive crisis

Neutrophil extracellular trap regulators in sickle cell disease: Modulation of gene expression of PADI4, neutrophil elastase, and myeloperoxidase during vaso‐occlusive crisis

Abstract Background Recent evidence suggests that generation of neutrophil extracellular traps (NETosis), one of the components of immunothrombosis, is associated with the pathogenesis of both venous thromboembolism and sickle cell disease (SCD). NETosis is a complex process regulated by several pro...

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Bibliographic Details
Main Authors: Bidossessi Wilfried Hounkpe, Francine Chenou, Igor de Farias Domingos, Evilazio Cunha Cardoso, Marcondes José de Vasconcelos Costa Sobreira, Aderson S. Araujo, Antonio Roberto Lucena‐Araújo, Pedro Vieira da Silva Neto, Adriana Malheiro, Nelson Abrahim Fraiji, Fernando Ferreira Costa, Marcos André C. Bezerra, Magnun Nueldo Nunes Santos, Erich Vinicius De Paula
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Research and Practice in Thrombosis and Haemostasis
Subjects:
elastase
neutrophil extracellular traps
peptidylarginine deiminase 4
sickle cell disease
vaso‐occlusive crisis
Online Access:https://doi.org/10.1002/rth2.12463

Internet

https://doi.org/10.1002/rth2.12463

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