Increased risk of genetic and epigenetic instability in human embryonic stem cells associated with specific culture conditions.

Increased risk of genetic and epigenetic instability in human embryonic stem cells associated with specific culture conditions.

The self-renewal and differentiation capacities of human pluripotent stem cells (hPSCs) make them a promising source of material for cell transplantation therapy, drug development, and studies of cellular differentiation and development. However, the large numbers of cells necessary for many of thes...

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Main Authors: Ibon Garitaonandia, Hadar Amir, Francesca Sesillo Boscolo, Gerald K Wambua, Heather L Schultheisz, Karen Sabatini, Robert Morey, Shannon Waltz, Yu-Chieh Wang, Ha Tran, Trevor R Leonardo, Kristopher Nazor, Ileana Slavin, Candace Lynch, Yingchun Li, Ronald Coleman, Irene Gallego Romero, Gulsah Altun, David Reynolds, Stephen Dalton, Mana Parast, Jeanne F Loring, Louise C Laurent
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0118307

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https://doi.org/10.1371/journal.pone.0118307

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