Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors

Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors

Sant-75 is a newly identified potent inhibitor of the hedgehog pathway. We designed a diversity-oriented synthesis program, and synthesized a series of Sant-75 analogues, which lays the foundation for further investigation of the structure–activity relationship of this important class of hedgehog-pa...

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Bibliographic Details
Main Authors: Chao Che, Song Li, Bo Yang, Shengchang Xin, Zhixiong Yu, Taofeng Shao, Chuanye Tao, Shuo Lin, Zhen Yang
Format: Article
Language:English
Published: Beilstein-Institut 2012-06-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
chemical diversity
diversity-oriented
hedgehog pathway
inhibitor
Sant-75
synthesis
Online Access:https://doi.org/10.3762/bjoc.8.94

Internet

https://doi.org/10.3762/bjoc.8.94

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