Dexamethasone Predisposes Human Erythroblasts Toward Impaired Lipid Metabolism and Renders Their ex vivo Expansion Highly Dependent on Plasma Lipoproteins

Dexamethasone Predisposes Human Erythroblasts Toward Impaired Lipid Metabolism and Renders Their ex vivo Expansion Highly Dependent on Plasma Lipoproteins

Cultures of stem cells from discarded sources supplemented with dexamethasone, a synthetic glucocorticoid receptor agonist, generate cultured red blood cells (cRBCs) in numbers sufficient for transfusion. According to the literature, however, erythroblasts generated with dexamethasone exhibit low en...

Full description

Bibliographic Details
Main Authors: Maria Zingariello, Claudio Bardelli, Laura Sancillo, Fiorella Ciaffoni, Maria Luisa Genova, Gabriella Girelli, Anna Rita Migliaccio
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Physiology
Subjects:
erythropoiesis
lipid metabolism
dexamethasone
ex vivo expansion
transfusion products
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00281/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.00281/full

Similar Items