Thrombospondin-1 Silencing Improves Lymphocyte Infiltration in Tumors and Response to Anti-PD-1 in Triple-Negative Breast Cancer

Thrombospondin-1 Silencing Improves Lymphocyte Infiltration in Tumors and Response to Anti-PD-1 in Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) is notoriously aggressive with a high metastatic potential, and targeted therapies are lacking. Using transcriptomic and histologic analysis of TNBC samples, we found that a high expression of thrombospondin-1 (TSP1), a potent endogenous inhibitor of angiogenesis...

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Bibliographic Details
Main Authors: Elie Marcheteau, Thomas Farge, Michaël Pérès, Guillaume Labrousse, Julie Tenet, Stéphanie Delmas, Maud Chusseau, Raphaëlle Duprez-Paumier, Camille Franchet, Florence Dalenc, Caroline Imbert, Justine Noujarède, Céline Colacios, Hervé Prats, Florence Cabon, Bruno Ségui
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
THBS1
TSP1
angiogenesis
metastasis
immunotherapy
tumor-infiltrating lymphocytes
Online Access:https://www.mdpi.com/2072-6694/13/16/4059

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https://www.mdpi.com/2072-6694/13/16/4059

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