The bifunctional enzyme, GenB4, catalyzes the last step of gentamicin 3′,4′-di-deoxygenation via reduction and transamination activities

The bifunctional enzyme, GenB4, catalyzes the last step of gentamicin 3′,4′-di-deoxygenation via reduction and transamination activities

Abstract Background New semi-synthetic aminoglycoside antibiotics generally use chemical modifications to avoid inactivity from pathogens. One of the most used modifications is 3′,4′-di-deoxygenation, which imitates the structure of gentamicin. However, the mechanism of di-deoxygenation has not been...

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Bibliographic Details
Main Authors: Xiaotang Chen, Hui Zhang, Shaotong Zhou, Mingjun Bi, Shizhou Qi, Huiyuan Gao, Xianpu Ni, Huanzhang Xia
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Microbial Cell Factories
Subjects:
Gentamicin
Di-deoxygenation
GenB4
Reduction activity
Transamination activity
Online Access:http://link.springer.com/article/10.1186/s12934-020-01317-0

Internet

http://link.springer.com/article/10.1186/s12934-020-01317-0

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