Affinity depletion versus relative protein enrichment: a side-by-side comparison of two major strategies for increasing human cerebrospinal fluid proteome coverage

Affinity depletion versus relative protein enrichment: a side-by-side comparison of two major strategies for increasing human cerebrospinal fluid proteome coverage

Abstract Cerebrospinal fluid (CSF) is in direct contact with the central nervous system. This makes human CSF an attractive source of potential biomarkers for neurologic diseases. Similarly to blood plasma, proteomic analysis of CSF is complicated by a high dynamic range of individual protein concen...

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Bibliographic Details
Main Authors: Eliska Jankovska, Marek Svitek, Karel Holada, Jiri Petrak
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Clinical Proteomics
Subjects:
Cerebrospinal fluid
Depletion
CNS
Biomarkers
LC–MS/MS
Mass spectrometry
Online Access:http://link.springer.com/article/10.1186/s12014-019-9229-1

Internet

http://link.springer.com/article/10.1186/s12014-019-9229-1

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